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Scientific Papers and Peer Reviewed Publications

PubMed/ National Institutes of Health

  • Propofol-induced sleep: efficacy and safety in patients with refractory chronic primary insomnia


  • Insomnia: pathophysiology and implications for treatment

  • Sleep, recovery, and metaregulation: explaining the benefits of sleep


  • The neurotransmitters of sleep


  • Sleep and Anesthesia – Common mechanisms of action

  • Unhealthy sleep-related behaviors--12 States, 2009

  • Transient insomnia versus chronic insomnia: a comparison study of sleep-related psychological/behavioral characteristics

  • Daytime alertness in patients with chronic insomnia compared with asymptomatic control subjects

  • Prevalence of causes of insomnia in primary care: a cross-sectional study


  • Propofol anesthesia and sleep: a high-density EEG study

  • New guidelines for diagnosis and treatment of insomnia


  • Pharmacokinetic-pharmacodynamic model for propofol for broad application in anaesthesia and sedation


  • Connectivity changes underlying spectral EEG changes during propofol-induced loss of consciousness


  • Secondary insomnia in the primary care setting: review of diagnosis, treatment, and management


  • The effect of insomnia definitions, terminology, and classifications on clinical practice


  • Targeting Slow Wave Sleep Deficiency in Late-Life Depression: A Case Series With Propofol


  • Recovery from Sleep Deprivation Occurs during Propofol Anesthesia 


  • Rested and refreshed after anesthesia? Overlapping neurobiologic mechanisms of sleep and anesthesia


  • Multimodal sleep, an innovation for treating chronic insomnia: case report and literature review

ClinicalTrials.gov/ National Institutes of Health

  • Evaluating the Efficacy and Safety of PROSOMNIA Sleep Therapy™ in Patients With Sleep Deprivation and Chronic Insomnia (PSHW)-NCT06644573


  • Efficacy and Safety Study of Propofol Infusion for Refractory Chronic Primary Insomnia (ClinicalTrials.gov Identifier: NCT02043977)


  • Effect of Propofol on Postoperative Sleep Quality in Elderly Patients With Sleep Disorders (ClinicalTrials.gov Identifier: NCT05325762)


  • The Relationship Between Different Doses of Propofol and the Occurrence of Dreams in Short Surgery Under General Anesthesia (ClinicalTrials.gov Identifier: NCT05173688)

Food and Drug Administration (FDA)

  • Approved Drug Products with Therapeutic Equivalence Evaluations 

  • Sleep Disorder (Sedative-Hypnotic) Drug Information


American Society of Anesthesiologists

  • Statement on Safe Use of Propofol

Legal Disclaimer and Affiliation Statement

These statements have not been approved by the FDA. The content of this website and any product or service offered on this website is provided for informational and educational purposes only. It is not medical advice and is not intended to diagnose, treat, cure, or prevent any disease, disorder, or medical condition. It should never replace any advice given to you by your physician or any other licensed healthcare provider.


PROSOMNIA Sleep™ (PS), PROSOMNIA Sleep Therapy™ (PSTx), and PROSOMNIA Sleep Health & Wellness™ (PSHW) provide professional sleep health services, including sleep education, coaching, and therapy. We do NOT manufacture, sell, or distribute sleep apnea oral devices or any medical equipment. Our services are focused solely on clinical sleep health support and wellness.



No Affiliation with PROSOMNUS® Technologies
We are NOT affiliated, associated, or connected in any way with PROSOMNUS® Technologies, its products, or its services. Any reference to our company, services, or offerings should not be interpreted as an endorsement, sponsorship, or partnership with PROSOMNUS® Technologies.


 Trademark™ 2025 PROSOMNIA Sleep and all Affiliations. All Rights Reserved. 

- PROSOMNIA Sleep™ Privacy Policy.  


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  • đź’¤ "Why We DON'T Sleep"

Why We DON’T Sleep

 â€śWhy We DON’T Sleep: Unlocking The Biological Secrets of Insomnia” đź’« Discover the science behind common sleep disorders, dive into the benefits of deep REM sleep, and learn all about PROSOMNIA Sleep Therapy and its revolutionary approach to overcoming chronic sleep issues. 💤💡

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